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Clinical Medicine
Author's Take
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174 Posts
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Prolonged transplant survival in preclinical models
In this episode, Leonardo Riella presents his manuscript detailing how a humanized mutein IL-2 selectively expands and boosts the function of mouse, non-human primate and human regulatory T cells, prolonging allograft survival...
Published April 24, 2024
Author's Take
A glycolysis/HIF1a axis in promoting G-MDSC activity and biofilm persistence during PJI is important
In this episode, Tammy Kielian, Kevin Garvin, Christopher Horn, and Prabhakar Arumugam describe how their study demonstrates the importance of a glycolysis/HIF1a axis in promoting G-MDSC anti-inflammatory activity and biofilm persistence during PJI...
Published April 23, 2024
Author's Take
Thrombotic microangiopathy is prevented in a case series of pig-to-human kidney xenotransplantation
In this episode, Jayme Locke and Maggie Jones-Carr explain the histologic outcomes of a series of brain-dead human recipients of a porcine kidney xenotransplant using exclusively FDA-approved medications, with and without anti-C5 monoclonal antibody...
Published March 1, 2024
Author's Take
Immune inhibitor receptor LAIR1 in gliomas and fibroblast–secreted collagen
In this episode, Shashwat Tripathi and Hinda Najem discuss how, using scRNA-seq, their analysis shows that CAFs, specifically the immune modulatory subtype, are increased in frequency as a function of glioma grade. Notably, collagen is a key ligand...
Published February 15, 2024
Author's Take
Pulmonary artery endothelial function and hypertension are impacted by RAB7 deficiency
In this episode, Laszlo Farkas explains that the results of this study indicate that reduced endothelial expression of endolysosomal RAB7...
Published February 1, 2024
Author's Take
Microglial activation and tau transmission aggravated by Galectin-3 in tauopathy
In this episode, Yijuang Chern and Jian Jing Siew discuss the novel role of Gal3 in the regulation of extracellular vesicles, promotion of pathogenic tau fibrillation, and microglial activation...
Published January 16, 2024
Author's Take
Numerous shared tumor antigens in breast cancer immunopeptidomes
In this episode, Eralda Kina and Claude Perreault explain how using proteogenomics, their manuscript identifies tumor-specific antigens in primary human breast cancers...
Published January 2, 2024
Author's Take
Suppression by regulatory T cells and Foxp3-mediated blockage of ryanodine receptor 2
In this episode, Xiaobo Wang, Shuang Geng, and Junchen Meng explain how this work reestablished the suppressive functions in Tconvs absence of Foxp3 indistinguishable from Tregs by simply blocking RyR2 expression...
Published December 15, 2023
Author's Take
Predicting diabetic kidney disease and mediating kidney injury in patients with endogenous adenine
In this episode, Kumar Sharma explains that urine adenine/creatinine is a marker for kidney failure in patients with diabetes, and endogenous adenine plays a potential causative role in diabetic kidney disease...
Published November 2, 2023
Author's Take
A link between serotonin and proliferation is revealed in Cronkhite-Canada syndrome patients
In this episode, Sarah Blutt explains how this work demonstrates the power of organoids to understand and develop new therapies for diseases...
Published November 1, 2023
Author's Take
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