[HTML][HTML] An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation
Different immune activation states require distinct metabolic features and activities in
immune cells. For instance, inhibition of fatty acid synthase (FASN), which catalyzes the
synthesis of long-chain fatty acids, prevents the proinflammatory response in macrophages;
however, the precise role of this enzyme in this response remains poorly defined. Consistent
with previous studies, we found here that FASN is essential for lipopolysaccharide-induced,
Toll-like receptor (TLR)-mediated macrophage activation. Interestingly, only agents that …
immune cells. For instance, inhibition of fatty acid synthase (FASN), which catalyzes the
synthesis of long-chain fatty acids, prevents the proinflammatory response in macrophages;
however, the precise role of this enzyme in this response remains poorly defined. Consistent
with previous studies, we found here that FASN is essential for lipopolysaccharide-induced,
Toll-like receptor (TLR)-mediated macrophage activation. Interestingly, only agents that …