In the light of the Matzinger's model of immune response, human heat shock proteins (HSPs)
as main 'danger signals'(tissue damage-associated molecular patterns-DAMPs) or/and
microbial HSPs as pathogen-associated molecular patterns (PAMPs) recognized by pattern
recognition receptors (PRR), may induce sarcoid granuloma by both infectious and non-
infectious factors in genetically different predisposed host. Regarding infectious causes of
sarcoid models, low-virulence strains of, eg mycobacteria and propionibacteria recognized …