[PDF][PDF] Genes and metabolic pathway of sarcoidosis: identification of key players and risk modifiers
MI Stjepanovic, V Mihailovic-Vucinic… - Archives of Medical …, 2019 - termedia.pl
MI Stjepanovic, V Mihailovic-Vucinic, V Spasovski, J Milin-Lazovic, V Skodric-Trifunovic…
Archives of Medical Science, 2019•termedia.plResults Subjects carrying the CC genotype of CYP27B1 rs10877012 have 10 times lower
odds of suffering from sarcoidosis. Moreover, DBP rs4588 AA genotype was shown to be a
susceptibility factor, where carriers of this genotype had eight times higher odds for
developing sarcoidosis. In addition, the A allele of the DBP gene (rs4588) was associated
with lower levels of 25 (OH) D in sarcoidosis patients. Conclusions These results suggest
that patients with vitamin D deficiency should be regularly tested for genetic modifiers that …
odds of suffering from sarcoidosis. Moreover, DBP rs4588 AA genotype was shown to be a
susceptibility factor, where carriers of this genotype had eight times higher odds for
developing sarcoidosis. In addition, the A allele of the DBP gene (rs4588) was associated
with lower levels of 25 (OH) D in sarcoidosis patients. Conclusions These results suggest
that patients with vitamin D deficiency should be regularly tested for genetic modifiers that …
Results
Subjects carrying the CC genotype of CYP27B1 rs10877012 have 10 times lower odds of suffering from sarcoidosis. Moreover, DBP rs4588 AA genotype was shown to be a susceptibility factor, where carriers of this genotype had eight times higher odds for developing sarcoidosis. In addition, the A allele of the DBP gene (rs4588) was associated with lower levels of 25 (OH) D in sarcoidosis patients.
Conclusions
These results suggest that patients with vitamin D deficiency should be regularly tested for genetic modifiers that are related to sarcoidosis in order to prevent development of serious forms of sarcoidosis.
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