Transforming growth factor-β gene polymorphisms in sarcoidosis patients with and without fibrosis
A Kruit, JC Grutters, HJT Ruven, CHM van Moorsel… - Chest, 2006 - Elsevier
Study objectives Pulmonary fibrosis develops in approximately 25% of patients with chronic
sarcoidosis. Transforming growth factor (TGF)-β1 plays a central role in fibrosis, and
accruing reports address the implication of TGF-β2 and TGF-β3 in this process. We
determined whether single-nucleotide polymorphisms (SNPs) in the TGF-β1, TGF-β2, and
TGF-β3 genes might contribute to pulmonary fibrosis in sarcoidosis patients. Setting A
hospital in the Netherlands. Design Five SNPs per TGF-β gene were investigated. Patients …
sarcoidosis. Transforming growth factor (TGF)-β1 plays a central role in fibrosis, and
accruing reports address the implication of TGF-β2 and TGF-β3 in this process. We
determined whether single-nucleotide polymorphisms (SNPs) in the TGF-β1, TGF-β2, and
TGF-β3 genes might contribute to pulmonary fibrosis in sarcoidosis patients. Setting A
hospital in the Netherlands. Design Five SNPs per TGF-β gene were investigated. Patients …
