Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands
P Constant, F Davodeau, MA Peyrat, Y Poquet, G Puzo… - Science, 1994 - science.org
P Constant, F Davodeau, MA Peyrat, Y Poquet, G Puzo, M Bonneville, JJ Fournié
Science, 1994•science.orgMost human peripheral blood γδ T lymphocytes respond to hitherto unidentified
mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that
stimulated proliferation of a major human γδ T cell subset were isolated and partially
characterized. One of these ligands, TUBag4, is a 5′ triphosphorylated thymidine-
containing compound, to which the three other stimulatory molecules are structurally related.
These findings support the hypothesis that some γδ T cells recognize nonpeptidic ligands.
mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that
stimulated proliferation of a major human γδ T cell subset were isolated and partially
characterized. One of these ligands, TUBag4, is a 5′ triphosphorylated thymidine-
containing compound, to which the three other stimulatory molecules are structurally related.
These findings support the hypothesis that some γδ T cells recognize nonpeptidic ligands.
Most human peripheral blood γδ T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human γδ T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5′ triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some γδ T cells recognize nonpeptidic ligands.
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