[HTML][HTML] Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling
D De Nardo, KR Balka, YC Gloria, VR Rao… - Journal of Biological …, 2018 - ASBMB
Toll-like receptors (TLRs) form part of the host innate immune system, in which they act as
sensors of microbial and endogenous danger signals. Upon TLR activation, the intracellular
Toll/interleukin-1 receptor domains of TLR dimers initiate oligomerization of a multiprotein
signaling platform comprising myeloid differentiation primary response 88 (MyD88) and
members of the interleukin-1 receptor–associated kinase (IRAK) family. Formation of this
myddosome complex initiates signal transduction pathways, leading to the activation of …
sensors of microbial and endogenous danger signals. Upon TLR activation, the intracellular
Toll/interleukin-1 receptor domains of TLR dimers initiate oligomerization of a multiprotein
signaling platform comprising myeloid differentiation primary response 88 (MyD88) and
members of the interleukin-1 receptor–associated kinase (IRAK) family. Formation of this
myddosome complex initiates signal transduction pathways, leading to the activation of …