[HTML][HTML] Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand-dependent activation
S Hauser, G Adelmant, P Sarraf, HM Wright… - Journal of Biological …, 2000 - ASBMB
The nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR) γ is a
ligand-activated transcription factor that regulates several crucial biological processes such
as adipogenesis, glucose homeostasis, and cell growth. It is also the functional receptor for
a new class of insulin-sensitizing drugs, the thiazolidinediones, now widely used in the
treatment of type 2 diabetes mellitus. Here we report that PPARγ protein levels are
significantly reduced in adipose cells and fibroblasts in response to specific ligands such as …
ligand-activated transcription factor that regulates several crucial biological processes such
as adipogenesis, glucose homeostasis, and cell growth. It is also the functional receptor for
a new class of insulin-sensitizing drugs, the thiazolidinediones, now widely used in the
treatment of type 2 diabetes mellitus. Here we report that PPARγ protein levels are
significantly reduced in adipose cells and fibroblasts in response to specific ligands such as …