Fecal immunoglobulin A against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: a …
KL Steiner, M Kabir, JW Priest, B Hossain… - Clinical Infectious …, 2020 - academic.oup.com
Clinical Infectious Diseases, 2020•academic.oup.com
In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but
not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed
antigen Cp23 at 12 months of age was associated with delayed time to subsequent
cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated
immunity in naturally exposed children.
not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed
antigen Cp23 at 12 months of age was associated with delayed time to subsequent
cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated
immunity in naturally exposed children.
Abstract
In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.
Oxford University Press