[HTML][HTML] Infection prophylaxis and management of viral infection

ES Clausen, L Zaffiri - Annals of translational medicine, 2020 - ncbi.nlm.nih.gov
ES Clausen, L Zaffiri
Annals of translational medicine, 2020ncbi.nlm.nih.gov
Viral infections are associated with significant morbidity and mortality in lung transplant
recipients. Importantly, several viral infections have been associated with the development
of chronic lung allograft dysfunction (CLAD). Community-acquired respiratory viruses
(CARV) such as influenza and respiratory syncytial virus (RSV), are frequently associated
with acute and chronic rejection. Cytomegalovirus (CMV) remains a significant burden in
regards to morbidity and mortality in lung transplant recipients. Epstein-Barr virus (EBV) is …
Abstract
Viral infections are associated with significant morbidity and mortality in lung transplant recipients. Importantly, several viral infections have been associated with the development of chronic lung allograft dysfunction (CLAD). Community-acquired respiratory viruses (CARV) such as influenza and respiratory syncytial virus (RSV), are frequently associated with acute and chronic rejection. Cytomegalovirus (CMV) remains a significant burden in regards to morbidity and mortality in lung transplant recipients. Epstein-Barr virus (EBV) is mostly involved with the development of post-transplant lymphoproliferative disorder (PTLD), a lymphoid proliferation that occurs in the setting of immunosuppression. On the other hand, the development of direct acting antivirals for hepatitis C virus (HCV) is changing the use of HCV-positive organs in transplantation. In this article we will focus on reviewing common viral infections that have a significant impact on lung transplant recipients looking at epidemiology, prevention and potential treatment.
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