[HTML][HTML] Human sirtuin 2 localization, transient interactions, and impact on the proteome point to its role in intracellular trafficking
HG Budayeva, IM Cristea - Molecular & Cellular Proteomics, 2016 - ASBMB
Human sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that primarily functions in the
cytoplasm, where it can regulate α-tubulin acetylation levels. SIRT2 is linked to cancer
progression, neurodegeneration, and infection with bacteria or viruses. However, the current
knowledge about its interactions and the means through which it exerts its functions has
remained limited. Here, we aimed to gain a better understanding of its cellular functions by
characterizing SIRT2 subcellular localization, the identity and relative stability of its protein …
cytoplasm, where it can regulate α-tubulin acetylation levels. SIRT2 is linked to cancer
progression, neurodegeneration, and infection with bacteria or viruses. However, the current
knowledge about its interactions and the means through which it exerts its functions has
remained limited. Here, we aimed to gain a better understanding of its cellular functions by
characterizing SIRT2 subcellular localization, the identity and relative stability of its protein …