Sensitivity of clinical isolates of human cytomegalovirus to 9-(1, 3-dihydroxy-2-propoxymethyl) guanine.
SA Plotkin, WL Drew, D Felsenstein, MS Hirsch - 1985 - cabidigitallibrary.org
SA Plotkin, WL Drew, D Felsenstein, MS Hirsch
1985•cabidigitallibrary.orgIsolates were tested in 3 laboratories across the USA. All 54 isolates and 6 laboratory stains
of cytomegalovirus were inhibited by 2.75 µg/ml (11 µmol/l) dihydroxypropoxymethylguanine
(DHPG), some by 0.4 µmol/l. The ID50 values ranged from 3.0 to 5.9 µmol/l. Peak
concentrations in blood in humans of 20-75 µmol/l" can be expected". newline˜ DW
FitzSimons
of cytomegalovirus were inhibited by 2.75 µg/ml (11 µmol/l) dihydroxypropoxymethylguanine
(DHPG), some by 0.4 µmol/l. The ID50 values ranged from 3.0 to 5.9 µmol/l. Peak
concentrations in blood in humans of 20-75 µmol/l" can be expected". newline˜ DW
FitzSimons
Abstract
Isolates were tested in 3 laboratories across the USA. All 54 isolates and 6 laboratory stains of cytomegalovirus were inhibited by 2.75 µg/ml (11 µmol/l) dihydroxypropoxymethylguanine (DHPG), some by 0.4 µmol/l. The ID50 values ranged from 3.0 to 5.9 µmol/l. Peak concentrations in blood in humans of 20-75 µmol/l "can be expected".newline˜D.W. FitzSimons
CABI Digital Library