An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA
K Takada, K Horinouchi, Y Ono, T Aya, T Osato… - Virus genes, 1991 - Springer
K Takada, K Horinouchi, Y Ono, T Aya, T Osato, M Takahashi, S Hayasaka
Virus genes, 1991•SpringerAbstract An Epstein-Barr virus (EBV)-producer line, designated Akata, was established from
a Japanese patient with Burkitt's lymphoma. The Akata line possessed the Burkitt's-type
chromosome translocation, t (8q-; 14q+), and was derived from the tumor cell. Akata cells
produced a large quantity of transforming virus upon treatment of cells with anti-
immunoglobulin antibodies (Takada, 1984). Southern blot analysis of viral DNA indicated
that the Akata EBV is nondefective and more representative of wild-type viruses. Akata cells …
a Japanese patient with Burkitt's lymphoma. The Akata line possessed the Burkitt's-type
chromosome translocation, t (8q-; 14q+), and was derived from the tumor cell. Akata cells
produced a large quantity of transforming virus upon treatment of cells with anti-
immunoglobulin antibodies (Takada, 1984). Southern blot analysis of viral DNA indicated
that the Akata EBV is nondefective and more representative of wild-type viruses. Akata cells …
Abstract
An Epstein-Barr virus (EBV)-producer line, designated Akata, was established from a Japanese patient with Burkitt's lymphoma. The Akata line possessed the Burkitt's-type chromosome translocation, t(8q-; 14q+), and was derived from the tumor cell. Akata cells produced a large quantity of transforming virus upon treatment of cells with anti-immunoglobulin antibodies (Takada, 1984). Southern blot analysis of viral DNA indicated that the Akata EBV is nondefective and more representative of wild-type viruses. Akata cells should be useful as a source of EBV.
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