Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of …
G Mao, H Li, X Ding, X Meng, G Wang… - Mechanisms of ageing and …, 2016 - Elsevier
Substantial evidence suggests that chronic human cytomegalovirus (hCMV) infection
contributes significantly to T-cell immunosenescence and adverse health outcomes in older
adults. As such, it is important to search for compounds with anti-hCMV properties. Studies
have shown that resveratrol, a sirtuin activator, suppresses hCMV infection. Here we report
suppressive effects of sirtinol, a sirtuin antagonist, on hCMV infection and its cellular and
molecular consequences. Human diploid fibroblast WI-38 cells were infected by hCMV …
contributes significantly to T-cell immunosenescence and adverse health outcomes in older
adults. As such, it is important to search for compounds with anti-hCMV properties. Studies
have shown that resveratrol, a sirtuin activator, suppresses hCMV infection. Here we report
suppressive effects of sirtinol, a sirtuin antagonist, on hCMV infection and its cellular and
molecular consequences. Human diploid fibroblast WI-38 cells were infected by hCMV …