Mesenchymal stromal cell-derived extracellular vesicles promote myeloid-biased multipotent hematopoietic progenitor expansion via toll-like receptor engagement
NA Goloviznina, SC Verghese, Y me Yoon… - Journal of Biological …, 2016 - ASBMB
Mesenchymal stromal cells (MSCs) present in the bone marrow microenvironment secrete
cytokines and angiogenic factors that support the maintenance and regenerative expansion
of hematopoietic stem and progenitor cells (HSPCs). Here, we tested the hypothesis that
extracellular vesicles (EVs) released by MSCs contribute to the paracrine crosstalk that
shapes hematopoietic function. We systematically characterized EV release by murine
stromal cells and demonstrate that MSC-derived EVs prompt a loss of HSPC quiescence …
cytokines and angiogenic factors that support the maintenance and regenerative expansion
of hematopoietic stem and progenitor cells (HSPCs). Here, we tested the hypothesis that
extracellular vesicles (EVs) released by MSCs contribute to the paracrine crosstalk that
shapes hematopoietic function. We systematically characterized EV release by murine
stromal cells and demonstrate that MSC-derived EVs prompt a loss of HSPC quiescence …
