Dual roles of group IID phospholipase A2 in inflammation and cancer
Y Miki, Y Kidoguchi, M Sato, Y Taketomi, C Taya… - Journal of Biological …, 2016 - ASBMB
Phospholipase A 2 enzymes have long been implicated in the promotion of inflammation by
mobilizing pro-inflammatory lipid mediators, yet recent evidence suggests that they also
contribute to anti-inflammatory or pro-resolving programs. Group IID-secreted
phospholipase A 2 (sPLA 2-IID) is abundantly expressed in dendritic cells in lymphoid
tissues and resolves the Th1 immune response by controlling the steady-state levels of anti-
inflammatory lipids such as docosahexaenoic acid and its metabolites. Here, we show that …
mobilizing pro-inflammatory lipid mediators, yet recent evidence suggests that they also
contribute to anti-inflammatory or pro-resolving programs. Group IID-secreted
phospholipase A 2 (sPLA 2-IID) is abundantly expressed in dendritic cells in lymphoid
tissues and resolves the Th1 immune response by controlling the steady-state levels of anti-
inflammatory lipids such as docosahexaenoic acid and its metabolites. Here, we show that …
