Polymorphisms in inflammasome'genes and susceptibility to HIV-1 infection
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2012•journals.lww.com
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was
investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4,
CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1–infected Brazilian subjects
and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in
IL1B were significantly associated to the HIV-1 infection. These findings supported the
previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis …
investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4,
CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1–infected Brazilian subjects
and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in
IL1B were significantly associated to the HIV-1 infection. These findings supported the
previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis …
Abstract
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1–infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.
Lippincott Williams & Wilkins