Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein
Several herpesviruses encode Fc receptors that may play a role in preventing antibody-
mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-
binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has
not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11
and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-
binding capabilities.
mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-
binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has
not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11
and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-
binding capabilities.
Abstract
Several herpesviruses encode Fc receptors that may play a role in preventing antibody-mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11 and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-binding capabilities.
American Society for Microbiology