[HTML][HTML] Recent trends in HIV-1 drug resistance
JD Siliciano, RF Siliciano - Current opinion in virology, 2013 - Elsevier
Highlights•Recent studies suggest that the prevalence of HIV-1 drug resistance is
declining.•This reflects the ability of antiretroviral therapy to halt viral evolution.•Recent
studies explain treatment failure without protease inhibitor resistance.Once considered an
inevitable consequence of HIV treatment, drug resistance is declining. This decline supports
the hypothesis that antiretroviral therapy can arrest replication and prevent the evolution of
resistance. Further support comes from excellent clinical outcomes, the failure of treatment …
declining.•This reflects the ability of antiretroviral therapy to halt viral evolution.•Recent
studies explain treatment failure without protease inhibitor resistance.Once considered an
inevitable consequence of HIV treatment, drug resistance is declining. This decline supports
the hypothesis that antiretroviral therapy can arrest replication and prevent the evolution of
resistance. Further support comes from excellent clinical outcomes, the failure of treatment …
