Interleukin-10 regulates fetal extracellular matrix hyaluronan production
Abstract Background/Purpose Mid-gestational (E14. 5) fetal wounds heal regeneratively with
attenuated inflammation and high levels of hyaluronan (HA) in their extracellular matrix
(ECM), whereas late-gestational (E18. 5) fetal wounds heal with scarring. IL-10 plays an
essential role in the fetal regenerative phenotype and is shown to recapitulate scarless
wound healing postnatally. We hypothesize a novel role of IL-10 as a regulator of HA in the
ECM. Methods Murine fetal fibroblasts (FFb) from C57Bl/6 and IL-10−/− mice were evaluated …
attenuated inflammation and high levels of hyaluronan (HA) in their extracellular matrix
(ECM), whereas late-gestational (E18. 5) fetal wounds heal with scarring. IL-10 plays an
essential role in the fetal regenerative phenotype and is shown to recapitulate scarless
wound healing postnatally. We hypothesize a novel role of IL-10 as a regulator of HA in the
ECM. Methods Murine fetal fibroblasts (FFb) from C57Bl/6 and IL-10−/− mice were evaluated …