CD28 expression in T cell aging and human longevity
Functional decrements of the immune system have a major contribution to aging and age-
related diseases. Here, we further characterize the decline in proportion of CD28-positive T
cells previously identified in centenarians. Cohorts of 97 centenarians, 40 subjects aged 70–
90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface
expression of CD28, CD4, and CD8 antigens. The significant decline in T cells expressing
CD28 (p< 10− 4 for comparisons between adults and either ELD or centenarians) affects …
related diseases. Here, we further characterize the decline in proportion of CD28-positive T
cells previously identified in centenarians. Cohorts of 97 centenarians, 40 subjects aged 70–
90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface
expression of CD28, CD4, and CD8 antigens. The significant decline in T cells expressing
CD28 (p< 10− 4 for comparisons between adults and either ELD or centenarians) affects …