Increased YKL-40 expression in patients with carotid atherosclerosis
AE Michelsen, CN Rathcke, M Skjelland, S Holm… - Atherosclerosis, 2010 - Elsevier
OBJECTIVE: We hypothesized a role for the inflammatory protein YKL-40 in atherogenesis
and plaque destabilization based on its role in macrophage activation, tissue remodeling,
and angiogenesis. METHODS: Serum YKL-40 levels were measured by enzyme
immunoassay in 89 patients with carotid atherosclerosis and 20 healthy controls. Carotid
expression of YKL-40 was examined by real time RT-PCR in 57 of the patients. Regulation
and effect of YKL-40 were examined in THP-1 monocytes. RESULTS: Our main findings …
and plaque destabilization based on its role in macrophage activation, tissue remodeling,
and angiogenesis. METHODS: Serum YKL-40 levels were measured by enzyme
immunoassay in 89 patients with carotid atherosclerosis and 20 healthy controls. Carotid
expression of YKL-40 was examined by real time RT-PCR in 57 of the patients. Regulation
and effect of YKL-40 were examined in THP-1 monocytes. RESULTS: Our main findings …