Microphthalmia transcription factor, a melanocytic nuclear protein critical for the embryonic
development and postnatal viability of melanocytes, is a master regulator in modulating
extracellular signals. Recently, microphthalmia transcription factor expression was shown to
be both a sensitive and specific marker of epithelioid melanoma. We investigated the
sensitivity of D5, an anti–microphthalmia transcription factor antibody, for diagnosis of clear
cell sarcoma (also known as malignant melanoma of soft parts). Immunoreactivity in a …