[HTML][HTML] Cyclin D1 is a ligand-independent co-repressor for thyroid hormone receptors
H Lin, L Zhao, S Cheng - Journal of Biological Chemistry, 2002 - ASBMB
Thyroid hormone receptors (TRs) are critical regulators of growth, differentiation, and
homeostasis. TRs function by regulating the expression of thyroid hormone (T3) target
genes in both ligand-dependent and-independent pathways. Distinct classes of co-
regulatory proteins modulate these two pathways. We show here a novel role of cyclin D1 as
a T3-independent co-repressor for TRs. Cyclin D1 interacted with TR in vitro and in cells in a
ligand-independent manner. Cyclin D1 acted to repress both the silencing activity of the …
homeostasis. TRs function by regulating the expression of thyroid hormone (T3) target
genes in both ligand-dependent and-independent pathways. Distinct classes of co-
regulatory proteins modulate these two pathways. We show here a novel role of cyclin D1 as
a T3-independent co-repressor for TRs. Cyclin D1 interacted with TR in vitro and in cells in a
ligand-independent manner. Cyclin D1 acted to repress both the silencing activity of the …