[HTML][HTML] Expression of Slug Is Regulated by c-Myb and Is Required for Invasion and Bone Marrow Homing of Cancer Cells of Different Origin [S]
In metastatic cancer cells, the process of invasion is regulated by several transcription
factors that induce changes required for migration and resistance to apoptosis. Slug (SNAI2,
Snail2) is involved in epithelial mesenchymal transition in physiological and in pathological
contexts. We show here that in embryonic kidney, colon carcinoma, chronic myeloid
leukemia-blast crisis, and in neuroblastoma cells, expression of Slug is transcriptionally
regulated by c-Myb via Myb binding sites in the 5′-flanking region and in the first intron of …
factors that induce changes required for migration and resistance to apoptosis. Slug (SNAI2,
Snail2) is involved in epithelial mesenchymal transition in physiological and in pathological
contexts. We show here that in embryonic kidney, colon carcinoma, chronic myeloid
leukemia-blast crisis, and in neuroblastoma cells, expression of Slug is transcriptionally
regulated by c-Myb via Myb binding sites in the 5′-flanking region and in the first intron of …