A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis
J Ji, XW Wang - Journal of hepatology, 2010 - journal-of-hepatology.eu
Multiple members of the let-7 family of miRNAs are often repressed in human cancers,
thereby promoting oncogenesis by derepressing targets such as HMGA2, K-Ras and c-Myc.
However, the mechanism by which let-7 miRNAs are coordinately repressed is unclear. The
RNA-binding proteins lin28 and lin28B block let-7 precursors from being processed to
mature miRNAs, suggesting that their overexpression might promote malignancy through
repression of let-7. Here we show that lin28 and lin28B are overexpressed in primary human …
thereby promoting oncogenesis by derepressing targets such as HMGA2, K-Ras and c-Myc.
However, the mechanism by which let-7 miRNAs are coordinately repressed is unclear. The
RNA-binding proteins lin28 and lin28B block let-7 precursors from being processed to
mature miRNAs, suggesting that their overexpression might promote malignancy through
repression of let-7. Here we show that lin28 and lin28B are overexpressed in primary human …