[PDF][PDF] Deadly teamwork: neural cancer stem cells and the tumor microenvironment
Cell stem cell, 2011•cell.com
Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells
(CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic
networks and the niche microenvironment. The CSC-microenvironment relationship is
complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the
cellular hierarchy.
(CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic
networks and the niche microenvironment. The CSC-microenvironment relationship is
complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the
cellular hierarchy.
Summary
Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy.
cell.com