High-performance liquid chromatographic method for the enantioselective analysis of mefloquine in plasma and urine
L Wallén, Ö Ericsson, I Wikström, U Hellgren - Journal of Chromatography B …, 1994 - Elsevier
An HPLC method for analysis of the enantiomers of the antimalarial drug mefloquine is
presented. A complete resolution of (−)-(11S, 2′ R) and (+)-(11R, 2′ S) erythro-mefloquine
from plasma and urine was obtained on a commercial AGP column. Mefloquine enantiomers
were detected by UV at 222 nm. The separation factor (α) at+ 20° C was 1.50. The limit of
determination (coefficient of variation 4.0%) for the enantiomeric ratio (11S, 2′ R)/(11R, 2′
S) is 15: 1 at a total mefloquine concentration of 1.6 mM.
presented. A complete resolution of (−)-(11S, 2′ R) and (+)-(11R, 2′ S) erythro-mefloquine
from plasma and urine was obtained on a commercial AGP column. Mefloquine enantiomers
were detected by UV at 222 nm. The separation factor (α) at+ 20° C was 1.50. The limit of
determination (coefficient of variation 4.0%) for the enantiomeric ratio (11S, 2′ R)/(11R, 2′
S) is 15: 1 at a total mefloquine concentration of 1.6 mM.