[PDF][PDF] Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia
M Škrtić, S Sriskanthadevan, B Jhas, M Gebbia… - Cancer cell, 2011 - cell.com
To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen
on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-
wide screen in yeast identified mitochondrial translation inhibition as the mechanism of
tigecycline-mediated lethality. Tigecycline selectively killed leukemia stem and progenitor
cells compared to their normal counterparts and also showed antileukemic activity in mouse
models of human leukemia. ShRNA-mediated knockdown of EF-Tu mitochondrial translation …
on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-
wide screen in yeast identified mitochondrial translation inhibition as the mechanism of
tigecycline-mediated lethality. Tigecycline selectively killed leukemia stem and progenitor
cells compared to their normal counterparts and also showed antileukemic activity in mouse
models of human leukemia. ShRNA-mediated knockdown of EF-Tu mitochondrial translation …
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.
M Skrtić, S Sriskanthadevan, B Jhas, M Gebbia… - Cancer cell, 2011 - europepmc.org
To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen
on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-
wide screen in yeast identified mitochondrial translation inhibition as the mechanism of
tigecycline-mediated lethality. Tigecycline selectively killed leukemia stem and progenitor
cells compared to their normal counterparts and also showed anti-leukemic activity in mouse
models of human leukemia. ShRNA-mediated knockdown of EF-Tu mitochondrial translation …
on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-
wide screen in yeast identified mitochondrial translation inhibition as the mechanism of
tigecycline-mediated lethality. Tigecycline selectively killed leukemia stem and progenitor
cells compared to their normal counterparts and also showed anti-leukemic activity in mouse
models of human leukemia. ShRNA-mediated knockdown of EF-Tu mitochondrial translation …