The lysosome turns fifty
C De Duve - Nature cell biology, 2005 - nature.com
C De Duve
Nature cell biology, 2005•nature.comIn the course of an investigation aimed at characterizing hepatic glucose 6-phosphatase, the
unrelated acid phosphatase of rat liver was serendipitously observed to be latent and
particle-bound in freshly prepared homogenates. Experiments designed to elucidate this
intriguing finding led, 50 years ago, to the discovery of lysosomes. This could not have
happened if strict adherence to a previously set programme had been mandatory.
unrelated acid phosphatase of rat liver was serendipitously observed to be latent and
particle-bound in freshly prepared homogenates. Experiments designed to elucidate this
intriguing finding led, 50 years ago, to the discovery of lysosomes. This could not have
happened if strict adherence to a previously set programme had been mandatory.
Abstract
In the course of an investigation aimed at characterizing hepatic glucose 6-phosphatase, the unrelated acid phosphatase of rat liver was serendipitously observed to be latent and particle-bound in freshly prepared homogenates. Experiments designed to elucidate this intriguing finding led, 50 years ago, to the discovery of lysosomes. This could not have happened if strict adherence to a previously set programme had been mandatory.
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