[HTML][HTML] Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production
A Hamacher-Brady, HA Stein, S Turschner… - Journal of Biological …, 2011 - ASBMB
The antimalarial agent artesunate (ART) activates programmed cell death (PCD) in cancer
cells in a manner dependent on the presence of iron and the generation of reactive oxygen
species. In malaria parasites, ART cytotoxicity originates from interactions with heme-
derived iron within the food vacuole. The analogous digestive compartment of mammalian
cells, the lysosome, similarly contains high levels of redox-active iron and in response to
specific stimuli can initiate mitochondrial apoptosis. We thus investigated the role of …
cells in a manner dependent on the presence of iron and the generation of reactive oxygen
species. In malaria parasites, ART cytotoxicity originates from interactions with heme-
derived iron within the food vacuole. The analogous digestive compartment of mammalian
cells, the lysosome, similarly contains high levels of redox-active iron and in response to
specific stimuli can initiate mitochondrial apoptosis. We thus investigated the role of …