A phase II clinical trial of mefloquine in patients with chloroquine-resistant falciparum malaria in Thailand
T Harinasuta, D Bunnag… - Bulletin of the World …, 1983 - ncbi.nlm.nih.gov
T Harinasuta, D Bunnag, WH Wernsdorfer
Bulletin of the World Health Organization, 1983•ncbi.nlm.nih.govA double-blind, randomized, dose-finding, phase II mefloquine trial was carried out in 147
adult male patients suffering from acute, uncomplicated, falciparum malaria and admitted to
the Hospital for Tropical Diseases, Bangkok, between January 1980 and April 1981.
Mefloquine was administered as a single oral dose of 500, 750, or 1000 mg (base) in the
form of the hydrochloride. The clinical and parasitological responses were satisfactory with
all three dosage regimens. The cure rates for the 1000-, 750-, and 500-mg doses were …
adult male patients suffering from acute, uncomplicated, falciparum malaria and admitted to
the Hospital for Tropical Diseases, Bangkok, between January 1980 and April 1981.
Mefloquine was administered as a single oral dose of 500, 750, or 1000 mg (base) in the
form of the hydrochloride. The clinical and parasitological responses were satisfactory with
all three dosage regimens. The cure rates for the 1000-, 750-, and 500-mg doses were …
Abstract
A double-blind, randomized, dose-finding, phase II mefloquine trial was carried out in 147 adult male patients suffering from acute, uncomplicated, falciparum malaria and admitted to the Hospital for Tropical Diseases, Bangkok, between January 1980 and April 1981. Mefloquine was administered as a single oral dose of 500, 750, or 1000 mg (base) in the form of the hydrochloride. The clinical and parasitological responses were satisfactory with all three dosage regimens. The cure rates for the 1000-, 750-, and 500-mg doses were 100%, 92.5%, and 95% respectively, over an observation period of 63 days.
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