Decline in total T cell count is associated with onset of AIDS, independent of CD4+ lymphocyte count: implications for AIDS pathogenesis
JB Margolick, AD Donnenberg, C Chu… - Clinical immunology and …, 1998 - Elsevier
We previously reported that blind T cell homeostasis, in which the total T cell count is
maintained but the CD4+ and CD8+ subset composition of the T cells can vary, fails
approximately 1.5 to 2.5 years before the onset of AIDS. The present study was premised on
the hypothesis that if failure of T cell homeostasis (ie, a decline in total T cell counts) is
important in the pathogenesis of AIDS, it should be a significant predictor of AIDS after
controlling for the CD4+ lymphocyte count. Data from 1556 homosexual men with sufficient …
maintained but the CD4+ and CD8+ subset composition of the T cells can vary, fails
approximately 1.5 to 2.5 years before the onset of AIDS. The present study was premised on
the hypothesis that if failure of T cell homeostasis (ie, a decline in total T cell counts) is
important in the pathogenesis of AIDS, it should be a significant predictor of AIDS after
controlling for the CD4+ lymphocyte count. Data from 1556 homosexual men with sufficient …